| Evidence |
Pathogenesis Endothelial cellss represent the largest cluster within the NPC population, containing a total of 10, 447 cells. At higher t-SNE resolution, this cluster can be further divided into four subclusters, representing periportal (Endo-pp) and pericentral (Endo-pc) Endothelial cellss and two clusters of liver sinusoidal Endothelial cellss (LSEC-1 and LSEC-2) that line the surface of liver sinusoids, Fig3A;Based on single-molecule fluorescence in situ hybridization results reported in a recent study on liver endothelial zonation (Halpern et al., 2018), we iden_x0002_tified a set of genes exhibiting Endo-pc-enriched expression, including Wnt9b, Rspo3, Cdh13, and Wnt2. Endo-pp expressed high levels of Ednrb, Jag1, Lrg1, Efnb1, Ltbp4, and Adgrg6, whereas LSEC-1 and LSEC-2 were marked by abundant expression of Fcgr2b and Gpr182, known LSEC markers |
