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ID 6907
Class Mammalia
Species Mouse
Tissue Intestine
Sample Tissue
Disease type Atypical teratoid/rhabdoid tumors
Cell type Microglia cells
Cell type (subtype) Microglia cells
Cell marker P2ry12, Fcrls, Siglech, Gpr34, TMEM119, TREM2, CD33, GPR34, CSF1R, MEF2C, SALL1, SALL3, CD68
Frequency
PubMed ID 31848709
Journal Acta Neuropathol
SCI IF 14.251
Evidence By using MG-specifc markers (e.g., P2ry12, Fig. 3b) and MAC-specifc markers (e.g., Ms4a7, Fig. 3c), we furtherclassifed cluster 4 cells as MG, and clusters 3, 7 and 17 as MACs.Fig.3f.RNA expression data of 33 ATRT patients [81] were segregated according to the ratio between MG marker gene expression (MG-specific genes used for annotation P2RY12, TMEM119, CD33, GPR34, TREM2, CSF1R, MEF2C, SALL1, SALL3) and CD68 expression.
Title Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance
Authors Viktoria Melcher et al.
Date 2019.12
Data available GSE141534