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ID 7792
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Regmyon
Cell type (subtype) Regmyon
Cell marker Myh3, Myh8
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence Especially interesting was the identification of three clusters ofnuclei related to skeletal muscle regeneration. One cluster, Cluster MuSC, is characterized by expression of Pax7, a markerof satellite cells. The second cluster, Cluster Myob, expresseshigh levels of Megf10, a marker of skeletal myoblasts (24). Thethird cluster, RegMyon, expresses Myh3 and Myh8 transcriptsthat encode embryonic and perinatal MyHC isoforms, respectively, which have been shown to be distinctive to regenerativemyofibers
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498