| ID |
6774 |
| Class |
Mammalia |
| Species |
Mouse |
| Tissue |
Hippocampus |
| Sample |
Tissue |
| Disease type |
brain |
| Cell type |
Neural cells |
| Cell type (subtype) |
Ivy cells |
| Cell marker |
Gad1, Nos, Lhx6, Cacna2d1, Slc32a8, Reln_, Vwa5a |
| Frequency |
|
| PubMed ID |
29912866
|
| Journal |
PLoS Biol |
| SCI IF |
7.706 |
| Evidence |
Continent 4 was identified as Ivy cells and medial ganglionic eminence (MGE)-derived neurogliaform cells. These cells expressed Cacna2d1, which we propose as a unique identifier of hippocampal neurogliaform/ivy cells, as well as Lhx6 and Nos1. They were divided into a Reln+ cluster identified with MGE-derived neurogliaform cells and a Reln_/Vwa5a+ cluster identified with Ivy cells. This continent is homologous to the isocortical Igtp class defined by Tasic and colleagues, which we hypothesize may represent isocortical neurogliaform cells of MGE origin; this hypothesis could be confirmed using fate mapping. |
| Title |
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics |
| Authors |
Kenneth D Harris et al. |
| Date |
2018.6 |
| Data available |
GSE99895 |
