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ID 7808
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Myoblasts
Cell type (subtype) Myoblasts
Cell marker Megf10
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence Especially interesting was the identification of three clusters of nuclei related to skeletal muscle regeneration. One cluster, Cluster MuSC, is characterized by expression of Pax7, a marker of satellite cells. The second cluster, Cluster Myob, expresses high levels of Megf10, a marker of skeletal myoblasts (24). The third cluster, RegMyon, expresses Myh3 and Myh8 transcriptsthat encode embryonic and perinatal MyHC isoforms, respectively, which have been shown to be distinctive to regenerativemyofibers
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498