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ID 6751
Class Mammalia
Species Mouse
Tissue Heart
Sample Tissue
Disease type Transplant arteriosclerosis
Cell type T cells
Cell type (subtype) T cells
Cell marker Cd4, Cd3g, Cd8b1
Frequency
PubMed ID 32689904
Journal Circ Res
SCI IF 14.467
Evidence our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).In addition, we also identified two other T cell populations enriched in the allografts, including a resting T cell population lacking expression of cytokines, which was annotated as na_ve T cells (cluster 4, expressing Ccr7 and Sell, but low levels of Cd44), and a population of Th17 cell (cluster 9, expressing Rorc, Rora, Ltb4r1, Il17a and Tnf, Figure 3F)
Title Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis
Authors Jingjing Cai et al.
Date 2020.9
Data available GSE149452, GSE140812 and GSE140968