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ID 6749
Class Mammalia
Species Mouse
Tissue Heart
Sample Tissue
Disease type Transplant arteriosclerosis
Cell type T cells
Cell type (subtype) T cells
Cell marker Cd4, Cd3g, Cd8b1
Frequency
PubMed ID 32689904
Journal Circ Res
SCI IF 14.467
Evidence our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).Allograft-enriched CD8+ T cells (cluster 1, 2, 3) displayed high expression of Gmzb, Fasl, and also expressed other cell cytotoxicity genes (Gzma, Gzmk, Gzmm, Prf1 and Tnfsf10, Figure 3F), indicating these subsets as CD8+ CTLs with potential cytotoxic properties
Title Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis
Authors Jingjing Cai et al.
Date 2020.9
Data available GSE149452, GSE140812 and GSE140968