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ID 6712
Class Mammalia
Species Mouse
Tissue Heart
Sample Tissue
Disease type Transplant arteriosclerosis
Cell type Dendritic cells
Cell type (subtype) Dendritic cells
Cell marker Flt3
Frequency
PubMed ID 32689904
Journal Circ Res
SCI IF 14.467
Evidence our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).we detected four distinct DC subpopulations (Figure 2G). Cluster 9, characterized by high expression of Cox6a2 and Siglech, was suggested to be plasmacytoid DC, a principal type I interferon-producing cell in the body26. Cluster 10 was most similar to CD209+ monocyte derived-DC27, with expression of Cd209a, Clec10a and monocyte markers CD14 and Fcgr3 (Figure 2C). Cluster 11 was enriched for DC maturation and migration marker Cacnb3, Fscn1, Ccr7, suggestive of CCR7+ migratory DC28, a population homing to the lymphatics. Cluster 12 was closest to XCR1+ cross-presenting DC29, in accordance with high expression of Xcr1.
Title Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis
Authors Jingjing Cai et al.
Date 2020.9
Data available GSE149452, GSE140812 and GSE140968