| Evidence |
our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).Several inflammasome related genes were also detected, mainly in isograft-enriched clusters. In contrast, proinflammatory chemokines (including Cxcl9, Cxcl10, Ccl5), and LY6C (Ly6c1, Ly6c2) were mainly expressed in allograft-enriched clusters (Figure 2E; Online Figure IVC), indicative of Ly6C monocyte-derived inflammatory macrophages (cluster 1, 3, 7) |
