| Evidence |
The VSMC lineage included c3, c4, and c13, which speci_cally expressed Rgs5, a gene that is abundantly expressed in arterial smooth muscle cells (Daniel et al., 2016; Gunaje et al., 2011), and Cxcl12, a chemokine-encoding gene that is highly expressed in the walls of the aorta and pulmonary trunk of the embryonic heart (embryonic day 12.5 [E12.5]) (Ivins et al., 2015). We also assessed the expression intensity distribution of contractile markers for smooth muscle cells, including Acta2, Tagln, Cnn1, and Myl9 (Sinha et al., 2014; Wilczewski et al., 2018). |
