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ID 6425
Class Mammalia
Species Mouse
Tissue Heart
Sample Tissue
Disease type Atherosclerosis
Cell type Macrophages
Cell type (subtype) Res-like macrophages
Cell marker Mrc1, Pf4, F13a1, Lyve1, Folr2, Ccl9, Ccl24, Cbr2, Txnip
Frequency
PubMed ID 29545365
Journal Circ Res
SCI IF 14.467
Evidence Res-like macrophages expressed genes previously associated with aortic resident macrophages (F13a1 and Lyve15, 13), chemokines (Ccl24 and Ccl9), and genes associated with M2-like macrophages (Folr2, Cbr2, and Mrc13). Interestingly, Res-like macrophages also showed homogenous expression of Pf4 (encoding CXCL4), a proatherogenic chemokine commonly considered as megakaryocyte/platelet specific, 22 and of Txnip (thioredoxin-interacting protein), pre- viously linked to macrophage and VSMC (vascular smooth muscle cells) inflammatory activation and atherosclerosis.
Title Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis
Authors Clement Cochain et al.
Date 2018.4
Data available GSE97310