| Evidence |
In the phenotypically modulated SMC cluster, markers of SMC differentiation including transgelin (Tagln; Fig. 2b) and calponin (Cnn1; Fig. 2c) showed a gradient of decreasing expression from the parental SMC lineage, and a gradient of increased expression for Lgals3 (a known marker of SMC phenotypic modulation; Fig. 2d), suggesting that these cells were undergoing SMC phenotypic modulation. There was marked upregulation of many other genes, including fibronectin 1 (FN1; Fig. 2e), osteoprotegerin (Tnfrsf11b; Fig. 2f) and collagen 1alpha1 (Col1alpha1; Extended Data Fig. 2a) in this cell group. |
