Search | Result
| ID | 6350 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | Heart |
| Sample | Organoids |
| Disease type | Experimental autoimmune myocarditis |
| Cell type | Inflammatory cells |
| Cell type (subtype) | Inflammation-associated cell |
| Cell marker | Hif1a |
| Frequency | |
| PubMed ID | 32431172 |
| Journal | Circulation |
| SCI IF | 23.61 |
| Evidence | Then, we obtained insights into immune cell clusters such as macrophage cluster 2 and T-helper (Th) 17 cells, related to the inflammatory response. Next, Hif1a was identified as a hallmark transcription factor (TF) of inflammation-associated cell clusters, and its inhibitor, PX-478, could alleviate the inflammatory response to EAM at the different phases. |
| Title | Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis |
| Authors | Xiumeng Hua et al. |
| Date | 2020.7 |
| Data available | GSE142564 |
