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ID 6720
Class Mammalia
Species Mouse
Tissue Heart
Sample Tissue
Disease type Transplant arteriosclerosis
Cell type Natural killer (NK) cells
Cell type (subtype) Natural killer (NK) cells
Cell marker Ncr1, Klrb1c, Gzma, Gzmb, Fasl, Klra3, Fcer1g
Frequency
PubMed ID 32689904
Journal Circ Res
SCI IF 14.467
Evidence our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).Another type of cytotoxic cells, NK cells (cluster 6), shared the expression programs with CD8+ CTL (Gzmb, Fasl), and displayed a specific strong expression of killer cell gene program (including Klrb1c, Klra3, Fcer1g, Gzma; Online Figure VE)
Title Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis
Authors Jingjing Cai et al.
Date 2020.9
Data available GSE149452, GSE140812 and GSE140968