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ID 5991
Class Mammalia
Species Mouse
Tissue Embryos
Sample Tissue
Disease type Normal
Cell type Endoderm cells
Cell type (subtype) Posterior gut tube
Cell marker Foxa2, Ttr, Lefty1, Eomes, Foxa1, Rhox5, Hnf4a, Plau, Hhex, Otx2, Afp, Trap1a, Xlr3a, Cdkn2a, Hoxb9
Frequency
PubMed ID 30959515
Journal Nature
SCI IF 49.962
Evidence Extended Data Fig. 4i; Gene_xpression plots of AVE (Cer1 and Dkk1), visceral_ndoderm (Eomes, Foxa1 and Ttr), and_isceral_ndoderm and EPI (Nodal) markers along EPI, and PrE and visceral_ndoderm lineages from E3.5_E5.5.Gene expression of AVE (Hhex and Lefty1), visceral endoderm (Foxa2 and Afp), visceral endoderm and EPI (Otx2 and Sox2) markers.Thus, despite the extensive morphological and transcriptional changes that take place between E7.5_nd_8.75, visceral endoderm lineage history is maintained through the expression of a core set of genes, including Rhox5, Trap1a, Xlr3a, Cdkn2a and Ttr;we compared the expression of markers of the emergent endodermal organs within both populations Nkx2-1 (thyroid and thymus)41, Irx1 (lung)42, Ppy (liver)43, Pdx1 (pancreas)44, Fabp1 (small intestine)45 and Hoxb9 (posterior gut tube)
Title The emergent landscape of the Mouse gut endoderm at single-cell resolution
Authors Sonja Nowotschin et al.
Date 2019.5
Data available GSE123046