Search | Result
| ID | 5707 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | Colon |
| Sample | Tissue |
| Disease type | Colorectal adenocarcinoma |
| Cell type | Macrophages |
| Cell type (subtype) | Activated human macrophages |
| Cell marker | GBP2, GBP2b, GBP3, GBP4, GBP5, GBP6, GBP7, GBP8, GBP9 |
| Frequency | |
| PubMed ID | 31375632 |
| Journal | Proc Natl Acad Sci U S A |
| SCI IF | 9.412 |
| Evidence | Guanylate-binding protein (GBP)-5 is a marker of IFNgamma-induced, classically activated Human macrophages (28). Although our study is focused on a murine model, we saw significantly higher levels of GBP transcripts in responding tumors, including those of GBP2 (4-fold), GBP2b (50.6-fold), GBP3, GBP4, GBP5, GBP6, GBP7, GBP8, and GBP9 on CD45+ cells, with GBP2b present exclusively in responders (Fig. 7E). |
| Title | Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. |
| Authors | Mohammad Rashidian et al. |
| Date | 2019.8 |
| Data available | NA |
