Search | Result
| ID | 5459 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | Brain |
| Sample | Tissue |
| Disease type | Gliomas |
| Cell type | Oligodendrocytes |
| Cell type (subtype) | Pri-OPCs |
| Cell marker | Pdgfra, Ppp1r14b, Ascl1, Btg2, Hes6 |
| Frequency | |
| PubMed ID | 30982771 |
| Journal | Cell Stem Cell |
| SCI IF | 20.86 |
| Evidence | Unexpectedly, the hGFAP-GFP+ cells also included cells with gene signatures associated with committed OPCs, marked by Pdgfra, and a primitive OPC subpopulation (pri-OPCs), which expressed low levels of Pdgfra and high levels of Olig1/2.A t-SNE plot based on differential gene expression revealed these two distinct OPC clusters OPCs (e.g., Pdgfra+ and Cspg4+) and pri-OPCs (e.g., Ppp1r14b+, Ascl1+, Btg2+, and Hes6+; |
| Title | Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis |
| Authors | Qinjie Weng et al. |
| Date | 2019.5 |
| Data available | GSE122871 |
