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ID 4903
Class Mammalia
Species Mouse
Tissue Blood
Sample Blood
Disease type chronic viral infection
Cell type CD8 T cells
Cell type (subtype) CD8 T cells
Cell marker NA
Frequency
PubMed ID 31606264
Journal Immunity
SCI IF 31.745
Evidence Cluster 2 was of particular interest given the high co-expression of Pdcd1, Tcf7, Slamf6, and Bcl2 and the relative lack of Gzmb, Havcr2, and markers of the cell cycle. This cluster is reminiscent of recently described TCF-1+ Tex progenitor cells in established exhaustion
Title TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
Authors Zeyu Chen et al.
Date 2019.1
Data available GSE131535