| Evidence |
Examples of these genes are histocompatibility 2, class II antigen A, alpha (H2-Aa) and beta 1 (H2-Ab1), encoding the alpha and beta chains of MHC class II in C57BL/6 Mouse, and Cd74, In addition to MHC class II-related genes, apCAFs expressed other unique markers such as Serum Amyloid A3 (Saa3), that was implicated as a protumorigenic factor in pancreatic CAFs (57) and Secretory Leukocyte Peptidase Inhibitor (Slpi), which was previously identified as a pro-inflammatory gene in dysplastic skin fibroblasts encoding the invariant chain. We therefore named these cells "antigen presenting CAFs" (apCAFs). |
