| Evidence |
We identified ten distinct cell populations across all samples within the SN (Fig. 1a, Supplementary Fig. 1, Supplementary Note 1), which included (i) astrocytes (GFAP) with two subtypes: astrocyte-1 population expressing neuroinflammatory genes (OLR1) and an astrocyte-2 (GINS3) population expressing genes associated with growth and reparative functionsï¼›(ii) oligodendrocytes (ODCs) (MOG, MOBP) with three subtypes discriminated by oligodendrocyte marker genes PALM2, LGALS1 & PPM1G, (iii) Endothelial cellss (RGS5), (iv) microglia cells (CSF1R), (v) oligodendrocyte precursor cells(OPCs) (VCAN), (vi) DaNs (TH and SLC6A3), neuronal population of the SN pars compacta (Supplementary Fig. 2) and(vii) GABAergic neurons, neuronal population of the SN pars reticulata expressing gamma-aminobutyric acid (GABA) receptors GABRA1 and GABRB2 and the enzymes GAD1 and GAD2 required for GABA neurotransmitter synthesis (Fig. 1a, c, Supplementary Data 2 and 3, Supplementary Fig. 2) |
