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ID 2325
Class Mammalia
Species Homo sapiens
Tissue Gut
Sample Organoids
Disease type Childhood Crohn's Disease
Cell type Epithelial cells
Cell type (subtype) Epithelial cells 1
Cell marker EPCAM, LGR5, ASCL2, EPHB2, RGMB
Frequency
PubMed ID 33290721
Journal Dev Cell
SCI IF 10.092
Evidence Among them were two clusters: a cluster with high expression of canonical adult-stem-cell genes, including leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), achaete-scute complex homolog 2 (ASCL2), ephrin type-B receptor 2 (EPHB2), and repulsive guidance molecule BMP co-receptor B (RGMB)
Title Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn Disease
Authors Rasa Elmentaite et al.
Date 2020.12
Data available NA