| Evidence |
n our data, 3 types of luminal cells were identified ac_x0002_cording to their high expression level of luminal markers including Keratin 8 (KRT8) and Keratin 18 (KRT18) in PCa samplesï¼›Results showed that Kallikrein Related Peptidase 4 (KLK4) and Solute Carrier Family 45 Member 3 (SLC45A3) were specifically expressed in type 1 luminal cell; thus, they could be used as specific markers for the detection of these cells (Fig. 2a, b). Ceruloplasmin (CP) was uniquely expressed in type 2 luminal cells, while Cellular Retinoic Acid Binding Protein 2 (CRABP2) was highly expressed in mesenchymal cell, as well as type 2 and type 3 luminal cells, suggesting a more suitable marker of CP for type 2 luminal cells (Fig. 2a, b). Type 3 luminal cells exhibited much higher expression levels of Beta-1, 4-Galactosyltransferase 1 (B4GALT1) and Interferon Alpha Inducible Protein 6 (IFI6) compared with other clusters, indicating that B4GALT1 and IFI6 may identify these cells (Fig. 2a, b). |
