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ID 2025
Class Mammalia
Species Homo sapiens
Tissue Cornea
Sample Tissue
Disease type Normal
Cell type Progenitor cells
Cell type (subtype) Limbal progenitor cells (LPCs)
Cell marker KRT19, IFITM3, KRT14, KRT15, SLC2A3, ITM2A, POSTN, TCF4, DCN, PLIN2DEGS1, MMP10, SLC6A6, LTB4R, SLPI
Frequency
PubMed ID 33388438
Journal Ocul Surf
SCI IF 12.336
Evidence The clustering result was annotated by the known markers including KRT12, KRT3 and GJA1 for differentiated cell; KRT14, KRT15 and KRT19 for progenitor; MKI67, BIRC5 and RRM2 for amplifying cell; TCF4, POSTN and A2M for LSC; TYR, TYRP1 and MLANA for melanocyte; and KRT4, KRT7 and KRT13 for conjunctival cells (Fig. 2F).C5 and C6 expressed some putative SC markers, such as SLC2A3, ITM2A, POSTN, and TCF4, at a middle level (Fig. 3A, D), indicating they are likely limbal progenitor cells (LPCs).Unlike the marker genes in LSC, the marker genes in LPC (C5 and C6), such as DCN, PLIN2 DEGS1, MMP10, IFITM3, SLC6A6, LTB4R, and SLPI,
Title Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of Human cornea
Authors De-Quan Li et al.
Date 2021.1
Data available GSE153515