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ID 3925
Class Mammalia
Species Homo sapiens
Tissue Prostate
Sample Tissue
Disease type Benign prostatic hyperplasia
Cell type Secretory cells
Cell type (subtype) Secretory epithelium
Cell marker KLK3
Frequency
PubMed ID 31094703
Journal JCI Insight
SCI IF 6.205
Evidence Figure 5.scRNA-Seq reveals altered cell subsets in BPH.(A) Two-dimensional projection (t-SNE plot) of single-cell transcriptomes stratifies prostate tissue cells (dots) into distinct clusters, identifiable by characteristic expression of marker genes, including (B) KRT13 (basal epithelium) (red intensity scales to maximum log2 expression), (C) KLK3 (secretory epithelium), and (D) DCN (fibroblasts). Additional cell type markers are shown in Supplemental Figure 6
Title Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis
Authors Lance W Middleton et al.
Date 2019.5
Data available All RNA-Seq and WES data are available from the database of Genotypes and Phenotypes (phs001698.v1.p1).