Search | Result

ID 3841
Class Mammalia
Species Homo sapiens
Tissue Pancreas
Sample Tissue
Disease type Pancreatic ductal adenocarcinoma
Cell type Fibroblasts
Cell type (subtype) ICAFs
Cell marker COL1A2, VIM, FAP, CXCL1, CCL2, CFD, CXCL12, DPT, LM, IL6, CXCL2, IL8
Frequency
PubMed ID 31197017
Journal Cancer Discov
SCI IF 29.497
Evidence In accordance with our previous iCAF and myCAF characterization (16), sub-cluster 1 had enriched expression of Interleukin 6 (IL6), Interleukin 8 (IL8) and chemokines such as CXCL1, CXCL2, CCL2, and CXCL12, and was therefore identified as iCAFs Our analysis enabled the identification of new marker genes for each CAF subtype. Strong expression of complement factor D (CFD) and matrix proteins such as lamin A/C (LMNA) and dermatopontin (DPT) marked iCAFs
Title Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
Authors Elyada Ela et al.
Date 2019.8
Data available GSE129458