Search | Result
| ID | 3840 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Pancreas |
| Sample | Tissue |
| Disease type | Pancreatic ductal adenocarcinoma |
| Cell type | Fibroblasts |
| Cell type (subtype) | CAFs |
| Cell marker | COL1A1, VIM, FAP, PDGFRA |
| Frequency | |
| PubMed ID | 31197017 |
| Journal | Cancer Discov |
| SCI IF | 29.497 |
| Evidence | Common fibroblast markers such as collagen type I alpha 1 chain (COL1A1), fibroblast activation protein alpha (FAP) and the mesenchymal cell marker vimentin (VIM) were expressed in both CAF subpopulations, confirming their fibroblast identity. Although Platelet Derived Growth Factor Receptor Alpha (PDGFRA) is commonly used as a CAF marker in different settings, we found that it is predominantly expressed in iCAFs (Fig. 3D). |
| Title | Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts |
| Authors | Elyada Ela et al. |
| Date | 2019.8 |
| Data available | GSE129457 |
