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ID 3529
Class Mammalia
Species Homo sapiens
Tissue Multiple tissues
Sample Cell line
Disease type Normal
Cell type Osteogenic cells
Cell type (subtype) Osteogenic cells
Cell marker ALPL, BGLAP, POSTN
Frequency
PubMed ID 30833796
Journal Nat Genet
SCI IF 27.603
Evidence Notably, however, and in accordance with the predicted pro-osteogenic activity, knockdown of ELK4 (encoding ETS transcription factor), SNAI2 (Snail family transcriptional repressor 2), MEF2A (myocyte enhancer factor 2A), NKX3-1 (NK3 homeobox 1), TEAD1 and TEAD4 (TEA-domain transcription factors 1 and 4), SMAD3 (SMAD family member 3), JUNB (JunB proto-oncogene; AP-1 transcription factor subunit), PITX1 (paired-like homeodomain 1) and FLI1 (Fli-1 proto-oncogene; ETS transcription factor) led to a significant decrease in ALP activity (Fig. 6b and Supplementary Fig. 6e), matrix mineralization (Supplementary Fig. 6f) and expression of osteogenic marker genes (Fig. 6d) in cells exposed to the osteogenic cocktail.
Title Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Authors Alexander Rauch et al.
Date 2019.4
Data available GSE79814, GSE35959, GSE27951, GSE15790, GSE73108, GSE44000, GSE48964, GSE29718, GSE15773, GSE9624, GSE15524, GSE39540, GSE12274, GSE113253