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ID 3465
Class Mammalia
Species Homo sapiens
Tissue Lung
Sample Tissue
Disease type Lymphangioleiomyomatosis
Cell type Epithelial cells
Cell type (subtype) Alveolar Epithelial-1
Cell marker AGER, HOPX, AQP4
Frequency
PubMed ID 33159078
Journal Nat Commun
SCI IF 12.121
Evidence In control lung, the alveolar epithelial cell (AEC)niche was divided into two canonical clusters: alveolar type 2(AT2), marked by the high differential expression of SFTPC, SFTPD, and SFTPA genes, and alveolar type-1 (AT1) cells, characterized by HOPX, AGER, and AQP4 gene expression
Title mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Authors Obraztsova K et al.
Date 2020.11
Data available GSE139819