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ID 3285
Class Mammalia
Species Homo sapiens
Tissue Lung
Sample Tissue
Disease type Systemic sclerosis-associated interstitial lung disease
Cell type Monocytes
Cell type (subtype) Monocytes
Cell marker FCN1, IL1B, IL1R2
Frequency
PubMed ID 31405848
Journal Ann Rheum Dis
SCI IF 16.102
Evidence AIF1- macrophages, CD3D- T lymphocytes, MS4A1- B lymphocytes, NKG7-natural killer cells, CD1C- dendritic cells, AGER- alveolar type 1 cells, SFTPC- alveolar type 2 cells, VWF- Endothelial cellss, LYVE1- lymphatic Endothelial cellss, COL1A2- fibroblasts, ACTA2- smooth muscle cells, TPSAB1- mast cells, SCGB3A1- goblet cells , SCGB3A2- club cells, FOXJ1- ciliated cells, KRT5- basal cells.Macrophages and monocytes were identified in seven separate clusters, which divided into three primary subgroups:the first expressing SPP1, CCL2, and MERTK (SPP1hi), the second expressing FABP4, INHBA, and SERPING1 (FABP4hi), and the third a population of monocytes expressing FCN1, IL1B, and IL1R2 (FCN1hi)
Title Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
Authors Eleanor Valenzi et al.
Date 2019.1
Data available GSE 128169