Search | Result

ID 3283
Class Mammalia
Species Homo sapiens
Tissue Lung
Sample Tissue
Disease type Systemic sclerosis-associated interstitial lung disease
Cell type Endothelial cells
Cell type (subtype) Lymphatic endothelial cells (LECs)
Cell marker LYVE1
Frequency
PubMed ID 31405848
Journal Ann Rheum Dis
SCI IF 16.102
Evidence AIF1- macrophages, CD3D- T lymphocytes, MS4A1- B lymphocytes, NKG7-natural killer cells, CD1C- dendritic cells, AGER- alveolar type 1 cells, SFTPC- alveolar type 2 cells, VWF- Endothelial cellss, LYVE1- lymphatic Endothelial cellss, COL1A2- fibroblasts, ACTA2- smooth muscle cells, TPSAB1- mast cells, SCGB3A1- goblet cells , SCGB3A2- club cells, FOXJ1- ciliated cells, KRT5- basal cells.Macrophages and monocytes were identified in seven separate clusters, which divided into three primary subgroups:the first expressing SPP1, CCL2, and MERTK (SPP1hi), the second expressing FABP4, INHBA, and SERPING1 (FABP4hi), and the third a population of monocytes expressing FCN1, IL1B, and IL1R2 (FCN1hi)
Title Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
Authors Eleanor Valenzi et al.
Date 2019.1
Data available GSE 128169