| Evidence |
CD4+ T cells comprised 6_7 clusters：resting cells expressingCCR7, SELL and TCF7, (corresponding to naive or TCM cells);three activation-associated clusters expressing IL2, TNF, and IL4Rat different levels; TRM-like resting and activated clustersexpressing canonical TRM markers CXCR6 and ITGA113, 33;and a distinct regulatory T cell (Treg) cluster expressing Tregdefininggenes FOXP3, IL2RA, and CTLA4 (Fig. 1c). CD8+ T cellscomprised four clusters distinct from CD4+ T cells and included.two TEM/TRM-like clusters expressing CCL5, cytotoxicityassociatedgenes (GZMB, GZMK), and TRM markers (CXCR6, ITGA1); an activated TRM/TEM cluster expressing IFNG, CCL4, CCL3; and clusters representing terminally differentiated effectorcells (TEMRA) expressing cytotoxic markers PRF1 and NKG7(Fig. 1c) |
