| Evidence |
We observed a large diversity among the lymphocyte compartment with CD8+ T cells (CD8A), Th17 cells (CCR6, IL23A), gammadelta T cells (TRGC1), activated CD4 T cells (LEF1, OX40), natural killer (NK) cells (NKG7), and a distinct cluster of activated CD8+ T cells (CSF2 and TOX2). We analyzed infected cells using automated thresholding over the viral signal (Figure S1J; STAR Methods). As expected, hepatocytes and apoptotic hepatocytes were strongly enriched among the infected cells (Figures 1H and _andS1K).S1K). Interestingly, we also detected viral reads in non-hepatocyte clusters, including two subsets of macrophages (CD163+ and TREM2+ populations, respectively), the CDC1 subset (XCR1+), as well as endothelial (OIT3+ cells) and epithelial cells (KRT7+) |
