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ID 2848
Class Mammalia
Species Homo sapiens
Tissue Kidney
Sample Organoids
Disease type Normal
Cell type Nephron
Cell type (subtype) Nephron progenitors
Cell marker CITED1, SIX1, SIX2, LYPD1, DAPL1
Frequency
PubMed ID 30846463
Journal Development
SCI IF 5.611
Evidence Cluster 2 showed expressionof the nephron progenitor markers SIX1, SIX2 and CITED1, as wellas the stromal marker PAX3 that has previously been associated withmyogenic Wilms' tumours.Cluster 0 (430 cells), the largestcluster, showed a more committed nephron progenitor signature, with expression of early renal vesicle markers PAX2, PAX8, LHX1and JAG1 as well as the Human NP markers LYPD1 and DAPL1.
Title Kidney micro-organoids in suspension culture as a scalable source of Human pluripotent stem cell-derived kidney cells
Authors Santhosh V Kumar et al.
Date 2019.3
Data available GSE117211, GSE108291