| ID |
2762 |
| Class |
Mammalia |
| Species |
Homo sapiens |
| Tissue |
Kidney |
| Sample |
Tissue |
| Disease type |
lupus nephritis |
| Cell type |
CD8 T cells |
| Cell type (subtype) |
CCR7+SELL+TCF7+ central memory T cells |
| Cell marker |
GZMK, LEF1, TCF7, CD69, KLF2 |
| Frequency |
|
| PubMed ID |
31209404
|
| Journal |
Nat Immunol |
| SCI IF |
20.479 |
| Evidence |
mostly CCR7+SELL+TCF7+ central memory T cells (CT0b; Fig. 4d and Supplementary Fig. 4h). The similar expression of CD69 in both clusters suggests that CT0b cells are more likely to be central memory than naive CD4+ T cells. Expression of TCF7, KLF2 and LEF1 may indicate an early central memory T-cell (Tcm) phenotype of CT0b cells, in contrast to the late effector phenotype of CT0a cells |
| Title |
The immune cell landscape in kidneys of patients with lupus nephritis |
| Authors |
Arnon Arazi et al. |
| Date |
2019.7 |
| Data available |
phs001457.v1.p1 |
