Search | Result
| ID | 1007 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Blood |
| Sample | Blood |
| Disease type | Ataxia-telangiectasia |
| Cell type | B cells |
| Cell type (subtype) | B cells |
| Cell marker | CD79A, CD22, PAX5, FCRL1, SERPINE1 |
| Frequency | |
| PubMed ID | 32366930 |
| Journal | Clinical Trial |
| SCI IF | 2.41 |
| Evidence | Regardless of clinical phenotype, all A-T participants exhibited downregulation of critical genes involved in B cell function (PAX5, CD79A, CD22, and FCRL1) and upregulation of several genes associated with senescence and malignancy, including SERPINE1. |
| Title | DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype |
| Authors | Sharon A McGrath-Morrow et al. |
| Date | 2020.5 |
| Data available | GSE142844 |
