Search | Result
| ID | 1856 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Colon |
| Sample | Tissue |
| Disease type | Pediatric-Onset Colitis |
| Cell type | Stem cells |
| Cell type (subtype) | Colonic stem cells |
| Cell marker | LGR5, ASCL2, SMOC2, FABP1, AQP8 |
| Frequency | |
| PubMed ID | 31730855 |
| Journal | Cell |
| SCI IF | 30.165 |
| Evidence | Colonic stem cells (ASCL2+LGR5+SMOC2+), absorptive (FXYD3+FABP1+SLC26A2+), and secretory (HEXIM1+METTL12+) progenitors (Figures S2A and S2B) were present in the three undifferentiated clusters. Colonocytes highly ex-pressed genes responsible for nutrient absorption and metabolism (FABP1 and AQP8), extracellular redox homeostasis(SEPP1), and a Cl?/HCO3?ion transporter (SLC26A3) involved in epithelial tight junction maintenance |
| Title | Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways |
| Authors | Bing H et al. |
| Date | 2019.11 |
| Data available | GSE121381 |
