Search | Result
| ID | 1919 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Colon |
| Sample | Tissue |
| Disease type | Pediatric-Onset Colitis |
| Cell type | Epithelial cells |
| Cell type (subtype) | Epithelial cells |
| Cell marker | C1, AC079767.4, ACP5, ADAM28, AFF3, ALG13, ALOX5, ANKRD13A, ANXA6, AP1B1, APPL1, ARHGAP17, ARHGAP24, ARHGAP25, ARL4A, ARPC3, ARRDC2, ATP6V1G1, BACH1, BACH2, BANK1, BASP1, BCAS4, BCL11A, BCL2A1, BCL7A, BIRC3, BLK, BLNK, BLOC1S2, BTG1, BTK, BTN2A2, C11orf31 |
| Frequency | |
| PubMed ID | 31730855 |
| Journal | Cell |
| SCI IF | 30.165 |
| Evidence | Colonic stem cells (ASCL2+LGR5+SMOC2+), absorptive (FXYD3+FABP1+SLC26A2+), and secretory (HEXIM1+METTL12+) progenitors (Figures S2A and S2B) were present in the three undifferentiated clusters. Colonocytes highly ex-pressed genes responsible for nutrient absorption and metabolism (FABP1 and AQP8), extracellular redox homeostasis(SEPP1), and a Cl?/HCO3?ion transporter (SLC26A3) involved in epithelial tight junction maintenance |
| Title | Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways |
| Authors | Bing H et al. |
| Date | 2019.11 |
| Data available | GSE121381 |
