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ID 1848
Class Mammalia
Species Homo sapiens
Tissue Colon
Sample Tissue
Disease type Pediatric-Onset Colitis
Cell type Tfh
Cell type (subtype) Tfh
Cell marker PDCD1, CXCR5, TOX2, MAGEH1, CORO1B, GNG4, GK, MAF, TIGIT, IL6ST, SMCO4, CTLA4, POU2AF1, TBC1D4, SLC9A9, IL21, IL6R, CXCL13, FBLN7, CD200, LINC01281, KIAA1324, SLC7A10, PVALB, HEYL, CEBPA, ASCL2, KSR2, C9orf16, CTSB, CD59, PPP1CC, TIAM1, MYL6B, CD4, LINC01
Frequency
PubMed ID 31730855
Journal Cell
SCI IF 30.165
Evidence These cells were partitioned into 9 groups using unsupervised graph clustering (Rosvall and Bergstrom, 2008) (Figure 1E), visualized by t-distributed stochastic neighbor embedding (t-SNE) (Amir el et al., 2013) and labeled according to marker gene expression (Figure S1D). Enteric glial cells, eosinophils, and neutrophils were not detected, probably due to technical limitations. Differentially expressed genes (DEGs) of all other subpopulations are provided in Table S57.
Title Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
Authors Bing H et al.
Date 2019.11
Data available GSE121381