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ID 1712
Class Mammalia
Species Homo sapiens
Tissue Breast
Sample Tissue
Disease type TNBC (triple-negative breast cancer)
Cell type Hypoxia-induced transcripts
Cell type (subtype) Hypoxia-induced transcripts
Cell marker ANGPTL4, ADM, PLAU
Frequency
PubMed ID 29091754
Journal Cell Rep
SCI IF 9.423
Evidence These included the following a mesenchymal/ stem (M/S) cluster (salmon color), which had significantly elevated expression of EGFR and elevated expression of genes associated with mesenchymal (VIM, ITGB1, and LAMC2) and stem cell-like (ITGA6 and ITGB4) states as well as hypoxia-induced transcripts (ANGPTL4, ADM, and PLAU)
Title A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer.
Authors Paul Savage et al.
Date 2017.1
Data available PRJNA374893, PRJNA39283