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ID 1664
Class Mammalia
Species Homo sapiens
Tissue Brain
Sample Organoids
Disease type Multiple sclerosis
Cell type CD8 T cells
Cell type (subtype) Memory CD8 T cells
Cell marker NKG7, GZMK, GZMA, CCL5, CCL4, PDCD1, CD69, GZMM, LGALS1, CXCR6, LGALS3, PRDM1
Frequency
PubMed ID 32948672
Journal Sci Immunol
SCI IF 13.423
Evidence Last, the CSF contained a cluster of memory CD8 T cells (CD8 memory CSF) that was marked by cytotoxic genes (CCL5, NKG7, GZMK, GZMA, GZMM, and CCL4) and genes related to tissue residence [CD69, LGALS1, LGALS3 (24, 34, 36), PDCD1, PRDM1 (41, 42), and CXCR6.
Title Transcriptomic and clonal characterization of T cells in the Human central nervous system
Authors Jenna L Pappalardo et al.
Date 2020.9
Data available phs002222.v1.p1, GSE157277, GSE155488