Search | Result
| ID | 1645 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Brain |
| Sample | NA |
| Disease type | AD |
| Cell type | Neural cells |
| Cell type (subtype) | Neurons |
| Cell marker | STMN2, DCX, RELN, NEUROD2, NEUROD6 |
| Frequency | |
| PubMed ID | 32632204 |
| Journal | Mol Psychiatry |
| SCI IF | 13.025 |
| Evidence | NPC (TOP2A, MKI67, CENPF, UBE2C) and radial glia (SLC1A3, SOX2, GLI3, HES1, PAX6, SOX9) (clusters 4, 6, 10, 16, and 24), neurons (STMN2, DCX, RELN, NEUROD2, NEUROD6) (clusters 0, 1, 2, 5, 7, 8, 12, 14, 15, 17, 18, 19, 20, and 21), astrocytes (GJA1, S100B) (clusters 9 and 13), microglia (TMEM119, OLFML3) (clusters 22 and 25), and additional glial cell types not contained in these groups (CRYAB, OLIG4, APOE, HLA-B, CEBPB) |
| Title | Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer disease-like pathology in human cerebral organoids |
| Authors | MarÃa José Pérez et al. |
| Date | 2020.7 |
| Data available | NA |
