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ID 1461
Class Mammalia
Species Homo sapiens
Tissue Brain
Sample Organoids
Disease type Healty
Cell type Progenitor cells
Cell type (subtype) Forebrain progenitors
Cell marker FOXG1
Frequency
PubMed ID 31168097
Journal Nature
SCI IF 49.962
Evidence IHC for neuronal (MAP2), dorsal forebrain progenitor (EMX1 and PAX6), CFuPN (CTIP2), CPN (SATB2), radial glia (SOX2), and proliferation (Ki67) markers in PGP1 (b2), 11a, GM08330, and HUES66 organoids at 3 months. c, In situ RNA hybridization for the IPC (EOMES a.k.a. TBR2), Cajal-Retzius (Reelin), and post-mitotic PN (TBR1) markers in 3 month PGP1 (b2), 11a, GM08330, and HUES66 organoids. d, IHC for the forebrain progenitor (FOXG1), outer radial glia (HOPX), post-mitotic PN (TBR1), and IPC (TBR2) markers in PGP1 (b2) organoids at 3 and 6 months (scale bars for B, C, D
Title Individual brain organoids reproducibly form cell diversity of the Human cerebral cortex.
Authors Velasco S et al.
Date 2019.6
Data available GSE129519