Search | Result
| ID | 1371 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Brain |
| Sample | Organoids |
| Disease type | Normal |
| Cell type | Synaptic cells |
| Cell type (subtype) | Pre-synaptic cells |
| Cell marker | SYP, GAP43, SYT4, SLC17A7 |
| Frequency | |
| PubMed ID | 32976764 |
| Journal | Stem Cell Reports |
| SCI IF | 6.022 |
| Evidence | Synaptic maturation is also observed in day 150 COs as shown by expression of the pre-synaptic marker, synaptophysin (SYP). These markers may be critical for synaptic propagation, as they correlate with the increased spiking activity and SBF that we detected in late-stage COs. For example, GAP43, SYT4, SYP, and SLC17A7 (Figure S4B, highlighted) are pre-synaptic markers enriched in excitatory neurons. |
| Title | Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development |
| Authors | Summer R Fair et al. |
| Date | 2020.1 |
| Data available | GSE157019 |
