| Evidence |
For CD8+ T cells na_ve (TCF7, LEF1, SELL, CCR7), cytotoxic (NKG7, CCL4, CST7, PRF1, GZMA, GZMB, IFNG, CCL3), exhaustion (PDCD1, TIGIT, LAG3, HAVCR2, CTLA4), and proliferation (MKI67, TYMS) signature scores were calculated. For CD4+ T cells na_ve (TCF7, LEF1, SELL, CCR7), cytotoxic (GZMB, PRF1, GNLY), exhaustion (PDCD1, TIGIT, LAG3, HAVCR2, CTLA4), and proliferation(MKI67, TYMS) signature scores were calculated;We observed significant activation in na_ve B cells (downregulation of FCER2 and upregulation ofSLAMF7) and expansion of antibody-secreting cells (ASCs) in moderate and severe samples compared to healthy and mild ones (Figures 4A-C). A distinct memory B cell population that has high expression in ITGAX and FCRL5 (Figure 4A), resembling a tissue-like memory B cell phenotype |
