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ID 1183
Class Mammalia
Species Homo sapiens
Tissue Blood
Sample Blood
Disease type breast cancer
Cell type CD8 T cells
Cell type (subtype) Cytotoxic Memory T Cells
Cell marker CD8, NKG7, GZMB, LAG3, PDCD1, GZMH, GNLY, FGFBP2, HLA-G
Frequency
PubMed ID 32826327
Journal Clin Cancer Res
SCI IF 9.492
Evidence Although the composition of the cells was largely similar, we identified one cluster (‘cluster 0') which was enriched in Pt. 4. Examination of genes differentially expressed in this cluster of cells suggested a cellular identity concordant with that of highly cytotoxic memory (TBX21-expressing) T cells, which had an abundance of MHC-I (HLA-A/B/C) and MHC-II (e.g., HLA-DRA, HLA-DRB5) family member expression as well as expression of cytolytic and immune checkpoint genes;Seven genes enriched in cluster 0 (PDCD1, NKG7, LAG3, GZMH, GZMB, GNLY, FGFBP2) and one gene strongly de-enriched in patient 4(HLA-G) were chosen as an 8 gene signature for downstream applications, including validation in a larger cohort of patients;
Title Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer
Authors Margaret L. Axelrod et al.
Date 2020.8
Data available NA